Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana,Journal of Natural Medicines

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Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana
Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2021-05-17 , DOI: 10.1007/s11418-021-01527-9
Sutin Kaennakam ₁ , Edwin Risky Sukandar ₂ , Thanawan Juntagoot ₃ , Pongpun Siripong ₄ , Santi Tip-Pyang ₂

Affiliation

Abstract

Four new xanthones, named schomburgones C-F (1‒4), along with six known xanthones (5‒10) were isolated from the stems of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines. Furanoxanthones 4‒6 showed potent cytotoxicity against four cell lines (KB, HeLa S3, MCF-7 and Hep G2) with IC₅₀ values in the range of 0.18‒9.95 µM.

Graphic abstract

中文翻译：

藤黄果茎中四种新的氧杂蒽酮及其细胞毒性

摘要

从Garcinia schomburgkiana的茎中分离出四种新的氧杂蒽酮，命名为 schomburgones C - F ( 1-4 )，以及六种已知的氧杂蒽酮 ( 5-10 ) 。它们的结构是通过光谱分析，特别是 1D 和 2D NMR 光谱确定的。评估了分离的化合物对五种人类癌细胞系的细胞毒性。Furanoxanthones 4-6显示了强的细胞毒性对四种细胞系（KB，HeLa细胞S3，MCF-7和Hep G2细胞）与集成电路_50个中的0.18-9.95范围内的值 μ M.

图形摘要

更新日期：2021-05-17

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