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Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana

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Abstract

Four new xanthones, named schomburgones C-F (1‒4), along with six known xanthones (5‒10) were isolated from the stems of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines. Furanoxanthones 4‒6 showed potent cytotoxicity against four cell lines (KB, HeLa S3, MCF-7 and Hep G2) with IC50 values in the range of 0.18‒9.95 µM.

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Acknowledgements

This research was funded by the Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok (KMUTNB), Contract no. 641069. We also thank Ms. Suttira Khumkratok, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Mahasarakham 44000, Thailand for the identification and deposition of the plant material.

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Correspondence to Sutin Kaennakam or Santi Tip-pyang.

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Kaennakam, S., Sukandar, E.R., Juntagoot, T. et al. Four new xanthones and their cytotoxicity from the stems of Garcinia schomburgkiana. J Nat Med 75, 871–876 (2021). https://doi.org/10.1007/s11418-021-01527-9

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  • DOI: https://doi.org/10.1007/s11418-021-01527-9

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