The auditory mismatch negativity, a component of the event-related potential elicited by an unexpected stimulus in a sequence of acoustic stimuli, provides an objective measure of the accuracy of the echoic information processing of the human brain in vivo. Auditory mismatch negativity is also a useful probe of cortical glutamatergic N-methyl-d-aspartate receptor activity and disturbance. Notably, auditory mismatch negativity is consistently impaired in schizophrenia. Because of the wide spectrum extending from bipolar affective illness and schizoaffective psychosis to typical schizophrenia, we examined the literature on auditory mismatch negativity in bipolar disorder with the aim to find any neurophysiological dysfunction concerning pre-attentive information processing shared by these clinical conditions. This focused review includes 26 original articles published in peer-reviewed journals and indexed in the National Institutes of Health National Library of Medicine (PubMed) search system. Overall, evidence is consistent with the finding that auditory mismatch negativity is impaired in bipolar disorder with psychotic features, even though to a lesser extent than in schizophrenia. It must be acknowledged that, in a few twin and family studies, mismatch negativity abnormalities were not specifically associated with bipolar disorder. In conclusion, auditory mismatch negativity research supports the involvement of the N-methyl-d-aspartate system in the pathophysiology of bipolar disorder, as previously assessed for schizophrenia, thus creating an intriguing trait d’union between these two mental illnesses and stimulating the development of novel therapeutic agents. With additional replication and validation, auditory mismatch negativity may be further considered as a correlate of a common psychopathology of schizophrenia and bipolar spectrum illnesses.

中文翻译：

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双相情感障碍中的听觉失配消极性：重点回顾

听觉失配负性是由一系列声学刺激中的意外刺激引起的事件相关电位的一个组成部分，它提供了对人脑回声信息处理准确性的客观测量体内. 听觉错配负性也是皮质谷氨酸能的有用探测ñ-甲基-d-天冬氨酸受体活性和干扰。值得注意的是，听觉错配消极性在精神分裂症中一直受到损害。由于从双相情感疾病和分裂情感性精神病到典型的精神分裂症的范围很广，我们检查了有关双相情感障碍中听觉错配负性的文献，旨在发现与这些临床条件共有的注意力前信息处理有关的任何神经生理功能障碍。这篇重点综述包括发表在同行评审期刊上的 26 篇原创文章，并被美国国立卫生研究院国家医学图书馆 (PubMed) 搜索系统收录。总体而言，证据与以下发现一致，即听觉错配消极性在具有精神病特征的双相情感障碍中受损，尽管程度低于精神分裂症。必须承认，在一些双胞胎和家庭研究中，错配阴性异常与双相情感障碍没有特别相关。总之，听觉错配负性研究支持 N-甲基-d-天冬氨酸系统在双相情感障碍的病理生理学中，如先前对精神分裂症的评估，从而产生了一个有趣的特质工会这两种精神疾病之间的关系，并刺激了新型治疗药物的发展。通过额外的复制和验证，可以进一步将听觉失配消极性视为精神分裂症和双相谱系疾病的常见精神病理学的相关因素。