A new UV-spectrophotometric method for determining the concentration of benzyl fragments in heparin benzyl esters is proposed. The method was validated for linearity, accuracy, and precision in terms of repeatability and intralaboratory reproducibility. The method is intended to characterize heparin benzyl esters, which are intermediates in the synthesis of low-molecular-weight heparin via hydrolytic depolymerization of high-molecular-weight heparin.

中文翻译：

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紫外分光光度法定量测定肝素苄酯中苯碎片的开发与验证

提出了一种新的紫外分光光度法测定肝素苄酯中苄基片段的浓度。在重复性和实验室内可重复性方面，该方法的线性，准确性和精密度均得到验证。该方法旨在表征肝素苄基酯，其是通过高分子量肝素的水解解聚合成低分子量肝素的中间体。