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Development and Validation of a UV-Spectrophotometric Method for Quantitative Determination of Benzene Fragments in Benzyl Esters of Heparin

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Pharmaceutical Chemistry Journal Aims and scope

A new UV-spectrophotometric method for determining the concentration of benzyl fragments in heparin benzyl esters is proposed. The method was validated for linearity, accuracy, and precision in terms of repeatability and intralaboratory reproducibility. The method is intended to characterize heparin benzyl esters, which are intermediates in the synthesis of low-molecular-weight heparin via hydrolytic depolymerization of high-molecular-weight heparin.

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Acknowledgments

The work was financially supported by the Ministry of Education and Science of the Russian Federation in the framework of the Project Part of a State Task for 2017 – 2019 (Project 15.2463.2017/4.6).

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Authors and Affiliations

  1. MIREA – Russian Technological University, M. V. Lomonosov Institute of Fine Chemical Technologies, 86 Vernadskogo Prosp., Moscow, 119571, Russia

    A. V. Matveev, E. S. Zhavoronok, L. E. Frumin, K. P. Yur’eva, L. E. Grebenkina, D. I. Prokorov, A. V. Panov & S. A. Kedik

  2. LLC Institute of Pharmaceutical Technologies, 21/32 Skolkovskoe Sh., Moscow, 121353, Russia

    E. S. Zhavoronok, A. V. Panov & S. A. Kedik

Authors
  1. A. V. Matveev
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  2. E. S. Zhavoronok
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  3. L. E. Frumin
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  4. K. P. Yur’eva
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  5. L. E. Grebenkina
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  6. D. I. Prokorov
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  7. A. V. Panov
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  8. S. A. Kedik
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Corresponding author

Correspondence to K. P. Yur’eva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 2, pp. 55 – 59, February, 2021.

L. E. Frumin is deceased.

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Matveev, A.V., Zhavoronok, E.S., Frumin, L.E. et al. Development and Validation of a UV-Spectrophotometric Method for Quantitative Determination of Benzene Fragments in Benzyl Esters of Heparin. Pharm Chem J 55, 197–201 (2021). https://doi.org/10.1007/s11094-021-02382-4

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  • DOI: https://doi.org/10.1007/s11094-021-02382-4

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