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Hydrogel as a Novel Drug Delivery System: Recent Advancements and Patents
Current Nanoscience ( IF 1.5 ) Pub Date : 2020-12-31 , DOI: 10.2174/1573413716999200626211915
Ruchi Singh 1 , Surya Goel 1 , Pankaj Kumar Sharma 1 , Abhinav Agarwal 1
Affiliation  

Background: A semisolid gel-like preparation constitutes with the cross-linked polymers, which may easily swell in the presence of water and incorporate the amount of drug substance known as ‘Hydrogel.’

Objective: To prepare the review on the hydrogels, leading ennoblements, classification, mechanism, recent patents, and evaluation parameters.

Methods: This review accrued by taking the help of online and offline journals, books, and other sources. This field includes new developments in the field of inventions in the novel drug delivery of hydrogels.

Results: The impact of the formulation of hydrogels is attracting the focus of the researchers expeditiously because of their nature, three-dimensional structure, compatibility with the other excipients was found enormously useful in the biomedical applications and pharmaceutical industries, less time consuming, better sustained and prolonged the effect. Currently, hydrogels are growing expeditiously for the intensive work done by the use of natural, synthetic, and semi-synthetic polymers for the transformation of hydrophobic and hydrophilic drugs into hydrogels as compared to develop the conventional gels.

Conclusion: The journey of hydrogel goes through with the numerous inventions research papers, reports, publications, and many other sources. The development arouses with the hydrogels in the use of wound dressing, making diapers, contact lens, etc. Nowadays, it is pivotally growing in the field of tissue engineering scaffolds, preparation of hydrophobic drugs into hydrogels, which is a critical challenge in prompt conditions.



中文翻译:

水凝胶作为新型药物输送系统:最新进展和专利

背景:半固体凝胶状制剂由交联聚合物组成,该交联聚合物在水的存在下可能容易溶胀,并掺入一定量的被称为“水凝胶”的药物。

目的:准备有关水凝胶,主要成分,分类,机理,最新专利和评估参数的综述。

方法:借助在线和离线期刊,书籍和其他来源的帮助,获得了此评论。该领域包括在水凝胶的新型药物递送中的发明领域中的新发展。

结果:由于其性质,三维结构,与其他赋形剂的相容性,水凝胶制剂的影响正迅速吸引研究人员的注意力,发现其在生物医学应用和制药行业中非常有用,耗时少,可持续性好并延长了效果。当前,与开发常规凝胶相比,通过使用天然,合成和半合成聚合物将疏水性和亲水性药物转化为水凝胶而进行的大量工作,水凝胶正在迅速增长。

结论:水凝胶的旅程经历了许多发明研究论文,报告,出版物和许多其他来源。水凝胶的发展引起了伤口敷料,尿布,隐形眼镜等的使用。如今,它在组织工程支架,将疏水性药物制备成水凝胶领域迅速发展,这在紧急情况下是一项严峻的挑战。

更新日期:2020-12-31
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