The study of protein folding is fundamental and important in the multidisciplinary field because a diversity of diseases, like Alzheimer’s and Parkinson’s are relevant to protein misfolding. The current thermodynamic and geometric approaches only phenomenologically describe but do not provide a mechanistic understanding of the competition between correct folding and misfolding. Here we present a model to understand the misfolding behavior. Considering the influence of dissipative strength for all possible sequences and comparing the folding time toward different compact structures, we obtain a phase diagram of the dissipative quantum phase transition that enables us to model the behavior. We also investigate how a perturbation in the Hamiltonian affects the transition point, which motivates us to explore possible manual interventions. Our results indicate that the manual intervention may be effective for some specific sequence but not for everyone. This approach is expected to lay a foundation for further studies on manual intervention in protein misfolding.

蛋白质折叠的研究在多学科领域中是基础性和重要的，因为像阿尔茨海默氏病和帕金森氏病这样的多种疾病都与蛋白质错误折叠有关。当前的热力学和几何方法仅是现象学上的描述，而没有提供对正确折叠和错折叠之间竞争的机械理解。在这里，我们提出一个模型来了解错误折叠行为。考虑耗散强度对所有可能序列的影响，并比较不同紧凑结构的折叠时间，我们获得了耗散量子相变的相图，该相图使我们能够对行为进行建模。我们还研究了哈密顿量的扰动如何影响过渡点，从而促使我们探索可能的人工干预。我们的结果表明，手动干预可能对某些特定顺序有效，但并非对所有人都有效。该方法有望为进一步研究蛋白质错误折叠的人工干预奠定基础。