Using Fura-2AM, a fluorescent Ca²⁺ indicator, we have shown for the first time that sigma-1 receptor antagonist - neuroleptic chlorpromazine - significantly inhibits the store-dependent Ca²⁺ entry induced by immunomodulators glutoxim as well as molixan and endoplasmic reticulum Са²⁺-ATPase inhi-bitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the regulation of store-dependent Ca²⁺ entry in macrophages.

中文翻译：

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Sigma-1受体配体氯丙嗪可减轻腹膜巨噬细胞中依赖于存储的Ca 2+进入。

使用荧光Ca ²⁺指示剂Fura-2AM，我们首次表明sigma-1受体拮抗剂-精神抑制药氯丙嗪-显着抑制免疫调节剂谷氨酰胺，莫利克森和内质网诱导的依赖于存储的Ca ²⁺进入Са ²⁺ -ATPase INHI-bitors毒胡萝卜素和大鼠腹腔巨噬细胞环匹阿尼酸。结果表明，sigma-1受体参与了巨噬细胞中依赖于存储的Ca ²⁺进入的调节。