Abstract

The review highlights recent reports of advances in quantitative neuroproteomics that use new methods to analyze brain functions. Functional neuroproteomics provides new insight into the mechanisms of brain function and neurodegenerative diseases by identifying expressed proteins and their interactions. Analysis of the brain’s proteome made it possible to establish the key proteins that underlie synaptic dysfunction in Alzheimer’s disease and to substantiate the important mechanisms for prognostic and diagnostic biomarkers of the disease.

中文翻译：

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神经蛋白质组学：多种蛋白质如何反映大脑功能

摘要

这篇综述重点介绍了使用新方法来分析大脑功能的定量神经蛋白质组学研究的最新报道。通过识别表达的蛋白质及其相互作用，功能神经蛋白质组学为大脑功能和神经退行性疾病的机制提供了新的见解。对大脑蛋白质组的分析使得可能建立起阿尔茨海默氏病突触功能障碍基础的关键蛋白质，并证实该疾病的预后和诊断生物标志物的重要机制。