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Neuroproteomics: How a Multitude of Proteins Reflect Brain Functions

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Abstract

The review highlights recent reports of advances in quantitative neuroproteomics that use new methods to analyze brain functions. Functional neuroproteomics provides new insight into the mechanisms of brain function and neurodegenerative diseases by identifying expressed proteins and their interactions. Analysis of the brain’s proteome made it possible to establish the key proteins that underlie synaptic dysfunction in Alzheimer’s disease and to substantiate the important mechanisms for prognostic and diagnostic biomarkers of the disease.

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ACKNOWLEDGMENTS

The author would like to thank Prof. N.A. Krupina and Prof. V.G. Zgoda for their valuable comments and support of this article.

Funding

The work was carried out within the framework of the Russian State Academies of Sciences Fundamental Research Program for 2013–2020.

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  1. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    O. A. Gomazkov

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Gomazkov, O.A. Neuroproteomics: How a Multitude of Proteins Reflect Brain Functions. Biol Bull Rev 11, 143–153 (2021). https://doi.org/10.1134/S2079086421020043

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