Background

Endocrine-disrupting compounds (EDCs) disrupt homeostasis via the dysregulation of hormone synthesis and metabolism. Bisphenol A (BPA) is widely used in consumer products, such as thermal receipts, water bottles, and baby bottles. However, BPA is also an EDC that acts as an estrogen agonist, and human exposure to BPA can lead to estrogenic effects. Consequently, manufacturers have started investigating the properties and effects of alternatives to BPA, molecules such as bisphenol F (BPF) and bisphenol S (BPS).

Objective

Although multiple studies have demonstrated the adverse effect of bisphenols, it remains unknown whether bisphenols affect human lung fibroblast cells. In this study, we investigated the cytotoxic effects of BPA, BPF, and BPS on the MRC5 human lung fibroblast cell line.

Results

We examined and compared the effects of BPA and its alternatives on cell proliferation, cell cycle progression, and apoptosis.

Conclusion

Brief exposures to low concentrations of BPA, BPF, and BPS had no effects on cell viability, cell cycle progression, or apoptosis among MRC5 human lung fibroblast cells.

中文翻译：

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双酚A替代物对人肺成纤维细胞MRC5细胞的细胞毒性作用

背景

破坏内分泌的化合物（EDC）通过激素合成和代谢失调来破坏体内平衡​​。双酚A（BPA）被广泛用于消费产品，例如热敏收据，水瓶和婴儿奶瓶。但是，BPA也是充当雌激素激动剂的EDC，人类接触BPA可能导致雌激素作用。因此，制造商已开始研究BPA替代品，双酚F（BPF）和双酚S（BPS）等分子的性质和作用。

客观的

尽管多项研究证明了双酚的不利影响，但双酚是否影响人肺成纤维细胞仍是未知的。在这项研究中，我们调查了BPA，BPF和BPS对MRC5人肺成纤维细胞系的细胞毒性作用。

结果

我们检查并比较了BPA及其替代品对细胞增殖，细胞周期进程和凋亡的影响。

结论

短暂暴露于低浓度的BPA，BPF和BPS对MRC5人肺成纤维细胞之间的细胞活力，细胞周期进程或细胞凋亡没有影响。