Abstract—

The purpose of this study was to detect changes in the serum concentrations of cytokines, heat shock proteins (HSP27 and HSP70), and antibodies against neural proteins, as well as to estimate their informational value in patients suffering from sensorineural hearing loss (SNHL). The study involved 38 men employed as flying personnel (flight instructors, aircraft commanders, and flight engineers) and 21 otherwise healthy men of comparable age. We detected specific cytokines that participate in immune inflammatory process in SNHL. The cytokine imbalance in the participants was characterized by excessive activation of the major inflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-4) cytokines, and a decrease in IL-2. Cytokine deregulation was accompanied by diminishment of HSP70 concentration, a HSP with immunomodulatory action. It was shown that neuroimmune reorganization manifested as enhancement of production of autoantibodies against neural proteins, in particular, S-100 and voltage-dependent calcium channels, which may be regarded as markers of the autoimmune process in SNHL. These results revealed the most informative indices that may be recommended as additional criteria in the diagnosis of SNHL.

中文翻译：

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感音神经性听力损失的免疫化学标记

摘要-

这项研究的目的是检测血清中细胞因子，热休克蛋白（HSP27和HSP70）和抗神经蛋白抗体的浓度变化，并评估其在感觉神经性听力损失（SNHL）患者中的信息价值。该研究涉及38名受雇为飞行人员的人（飞行教练，飞机指挥官和飞行工程师）和21名其他可比年龄的健康男子。我们检测到参与SNHL免疫炎症过程的特定细胞因子。参与者中的细胞因子失衡的特征在于主要炎症细胞因子（IL-1β，TNF-α）和抗炎症细胞因子（IL-4）的过度活化以及IL-2的降低。细胞因子的失调伴随着HSP70浓度的降低，HSP70是一种具有免疫调节作用的HSP。结果表明，神经免疫重组表现为针对神经蛋白（尤其是S-100和电压依赖性钙通道）的自身抗体产生的增强，这些蛋白可被视为SNHL中自身免疫过程的标志物。这些结果揭示了最具信息价值的指数，可以推荐作为SNHL诊断中的附加标准。