Abstract—
The purpose of this study was to detect changes in the serum concentrations of cytokines, heat shock proteins (HSP27 and HSP70), and antibodies against neural proteins, as well as to estimate their informational value in patients suffering from sensorineural hearing loss (SNHL). The study involved 38 men employed as flying personnel (flight instructors, aircraft commanders, and flight engineers) and 21 otherwise healthy men of comparable age. We detected specific cytokines that participate in immune inflammatory process in SNHL. The cytokine imbalance in the participants was characterized by excessive activation of the major inflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-4) cytokines, and a decrease in IL-2. Cytokine deregulation was accompanied by diminishment of HSP70 concentration, a HSP with immunomodulatory action. It was shown that neuroimmune reorganization manifested as enhancement of production of autoantibodies against neural proteins, in particular, S-100 and voltage-dependent calcium channels, which may be regarded as markers of the autoimmune process in SNHL. These results revealed the most informative indices that may be recommended as additional criteria in the diagnosis of SNHL.
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The study was supported by the state assignment of the East Siberian Institute of Medicoecological Research.
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Statement of compliance with standards of research involving humans as subjects. Patients were examined in accordance with the “Ethical Principles for Medical Research Involving Human Subjects” Helsinki Declaration and its 2000 amendments and “Rules of Clinical Practice in the Russian Federation” approved by the Order of the Ministry of Health of the Russian Federation no. 266 (June 19, 2003). Informed consent was obtained from all individual participants involved in the study. The approval of the local ethical committee (protocol no. 5, November 14, 2012) was obtained.
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Bodienkova, G.M., Boklazhenko, E.V. Immunochemical Markers of Sensorineural Hearing Loss. Neurochem. J. 15, 91–94 (2021). https://doi.org/10.1134/S1819712421010037
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DOI: https://doi.org/10.1134/S1819712421010037