We did a systematic review and meta-analysis, aiming to examine the association of available polymorphisms in the receptor for advanced glycation end products (AGER) gene with the risk of type 2 diabetes. Literature search, eligibility assessment, and data extraction were independently performed by two authors. Risk was expressed as by odds ratio (OR) and 95% confidence interval (CI) under the random-effects model. A total of 26 publications, involving 29 independent studies (8,318 patients with type 2 diabetes and 5,589 healthy or orthoglycemic controls) were included in this meta-analysis. Six polymorphisms in AGER gene, rs2070600, rs1800624, rs1800625, rs184003, rs3134940, and rs55640627, were eligible for inclusion. Overall analyses indicated that the mutations of rs1800624 (–374A) and rs55640627 (2245A) were associated with a significantly increased risk of type 2 diabetes (OR = 1.17 and 1.55, 95% CI: 1.00 to 1.38 and 1.21 to 1.98, respectively). Subsidiary analyses revealed that the mutation of rs2070600 was associated with 2.13-folded increased risk of type 2 diabetes in Caucasians (95% CI: 1.28 to 3.55), and the mutation of rs1800624 was associated with 1.57-folded increased risk in South Asians (95% CI: 1.09 to 2.25), with no evidence of heterogeneity (I²: 42.5% and 44.5%). There were low probabilities of publication bias for all studied polymorphisms. Taken together, our findings indicate an ethnicity-dependent contribution of AGER gene in the pathogenesis of type 2 diabetes, that is, rs2070600 was a susceptibility locus in Caucasians, yet rs1800624 in South Asians.

我们进行了系统回顾和荟萃分析，旨在检查晚期糖基化终产物 ( AGER ) 基因受体中可用的多态性与 2 型糖尿病风险的关联。文献检索、资格评估和数据提取由两位作者独立进行。在随机效应模型下，风险以优势比 (OR) 和 95% 置信区间 (CI) 表示。该荟萃分析共纳入26 篇出版物，涉及 29 项独立研究（8,318 名2 型糖尿病患者和5,589 名健康或血糖控制组）。AGER中的六个多态性rs2070600、rs1800624、rs1800625、rs184003、rs3134940 和 rs55640627 基因符合纳入条件。总体分析表明，rs1800624 (–374A) 和 rs55640627 (2245A) 的突变与 2 型糖尿病风险显着增加相关（OR = 1.17 和 1.55，95% CI：分别为 1.00 至 1.38 和 1.21 至 1.98）。辅助分析显示，rs2070600 突变与高加索人 2 型糖尿病风险增加 2.13 倍相关（95% CI：1.28 至 3.55），rs1800624 突变与南亚人风险增加 1.57 倍相关（95 % CI：1.09 至 2.25），无异质性证据（I ²: 42.5% 和 44.5%)。所有研究的多态性的发表偏倚概率都很低。总之，我们的研究结果表明AGER基因在 2 型糖尿病发病机制中的种族依赖性贡献，即 rs2070600 在高加索人中是易感基因座，而在南亚人中是 rs1800624。