Susceptibility of six polymorphisms in the receptor for advanced glycation end products to type 2 diabetes: a systematic review and meta-analysis

Hao Cheng; Wenbin Zhu; Mou Zhu; Yan Sun; Xiaojie Sun; Di Jia; Chao Yang; Haitao Yu; Chunjing Zhang

doi:10.1507/endocrj.EJ21-0130

ORIGINAL

Susceptibility of six polymorphisms in the receptor for advanced glycation end products to type 2 diabetes: a systematic review and meta-analysis

Hao Cheng, Wenbin Zhu, Mou Zhu, Yan Sun, Xiaojie Sun, Di Jia, Chao Yang, Haitao Yu, Chunjing Zhang

Author information

Hao Cheng
Department of Clinics, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Wenbin Zhu
Department of Molecular Biology Laboratory, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Mou Zhu
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Yan Sun
Department of Clinical Pathogen Microbiology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Xiaojie Sun
Department of Clinical Biochemistry, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Di Jia
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Chao Yang
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Haitao Yu
Department of Cell Biology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China
Chunjing Zhang
Department of Biochemistry and Molecular Biology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China

Keywords: Type 2 diabetes, Receptor for advanced glycation end products, Polymorphism, Association, Systematic review and meta-analysis

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2021 Volume 68 Issue 8 Pages 993-1010

DOI https://doi.org/10.1507/endocrj.EJ21-0130

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Abstract

We did a systematic review and meta-analysis, aiming to examine the association of available polymorphisms in the receptor for advanced glycation end products (AGER) gene with the risk of type 2 diabetes. Literature search, eligibility assessment, and data extraction were independently performed by two authors. Risk was expressed as by odds ratio (OR) and 95% confidence interval (CI) under the random-effects model. A total of 26 publications, involving 29 independent studies (8,318 patients with type 2 diabetes and 5,589 healthy or orthoglycemic controls) were included in this meta-analysis. Six polymorphisms in AGER gene, rs2070600, rs1800624, rs1800625, rs184003, rs3134940, and rs55640627, were eligible for inclusion. Overall analyses indicated that the mutations of rs1800624 (–374A) and rs55640627 (2245A) were associated with a significantly increased risk of type 2 diabetes (OR = 1.17 and 1.55, 95% CI: 1.00 to 1.38 and 1.21 to 1.98, respectively). Subsidiary analyses revealed that the mutation of rs2070600 was associated with 2.13-folded increased risk of type 2 diabetes in Caucasians (95% CI: 1.28 to 3.55), and the mutation of rs1800624 was associated with 1.57-folded increased risk in South Asians (95% CI: 1.09 to 2.25), with no evidence of heterogeneity (I²: 42.5% and 44.5%). There were low probabilities of publication bias for all studied polymorphisms. Taken together, our findings indicate an ethnicity-dependent contribution of AGER gene in the pathogenesis of type 2 diabetes, that is, rs2070600 was a susceptibility locus in Caucasians, yet rs1800624 in South Asians.

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