A tripeptide Boc-L-Pro- m -ABA-Aib-OMe was synthesized where meta -aminobenzoic acid ( m -ABA), a rigid non-coded γ-amino acid is placed as middle residue. Single crystal X-ray diffraction study indicates that the peptide self-assembles into helical motif through intermolecular hydrogen bonding interaction N–H···O, C–H···O, π···π interaction and van der Waals interaction. HR-TEM image reveals the formation of fibril in the solid state.

中文翻译：

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刚性非编码γ-氨基酸插入的三肽的固态自组装和形态

合成了三肽Boc-L-Prom -ABA-Aib-OMe，其中间氨基苯甲酸（m -ABA）（一种刚性的未编码γ-氨基酸）位于中间残基。单晶X射线衍射研究表明，该肽通过分子间氢键相互作用N–H···O，CH–H···O，π···π相互作用和范德华相互作用自组装成螺旋基序。HR-TEM图像显示出固态的原纤维形成。