Purpose

To investigate whether abnormal retinal microcirculation correlates with retinal neuronal changes in untreated diabetic eyes without macular edema.

Methods

This study enrolled 29 diabetic patients without diabetic retinopathy (DR), 18 patients with mild non-proliferative diabetic retinopathy (NPDR), 15 patients with moderate NPDR, 14 patients with severe NPDR, 27 patients with proliferative diabetic retinopathy (PDR), and 25 healthy control subjects. Pattern electroretinography (PERG) and optical coherence tomography angiography (OCT-A) tests were performed.

Results

Differences in the mean values for the area, acircularity index, and perimeter of foveal avascular zone were statistically significant between the healthy control group and the diabetic patients (P  < 0.05 for all). P50 and N95 amplitudes were statistically significantly lower in the PDR group compared to diabetic patients without DR, control, and moderate NPDR groups (P  < 0.05 for all). The whole retina vessel densities in superficial and deep capillary plexus were lower in the PDR group compared to the diabetic patients without DR and control group (P < 0.05 for all). There were statistically significant positive correlations between the amplitudes of the P50 and N95 waves with the vessel densities.

Conclusion

The existence of significant correlations between PERG and OCT-A parameters in diabetic patients has shown that vascular and neuronal changes in the macula affect each other in diabetic patients.

中文翻译：

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糖尿病视网膜病变患者黄斑神经元和微血管成分的评估

目的

研究异常的视网膜微循环是否与未经治疗的无黄斑水肿糖尿病眼的视网膜神经元变化相关。

方法

本研究招募了 29 名无糖尿病视网膜病变 (DR) 的糖尿病患者、18 名轻度非增殖性糖尿病视网膜病变 (NPDR) 患者、15 名中度 NPDR 患者、14 名重度 NPDR 患者、27 名增殖性糖尿病视网膜病变 (PDR) 患者和 25健康对照受试者。进行了模式视网膜电图 (PERG) 和光学相干断层扫描血管造影 (OCT-A) 测试。

结果

健康对照组与糖尿病患者中心凹无血管区面积、圆度指数和周长的平均值差异有统计学意义（均P   < 0.05）。与没有 DR 的糖尿病患者、对照组和中度 NPDR 组相比，PDR 组的 P50 和 N95 幅度在统计学上显着降低（P   < 0.05）。与无 DR 的糖尿病患者和对照组相比，PDR 组的浅层和深部毛细血管丛的全视网膜血管密度较低（均P  < 0.05）。P50 和 N95 波的振幅与血管密度之间存在统计学上显着的正相关。

结论

糖尿病患者 PERG 和 OCT-A 参数之间存在显着相关性表明，糖尿病患者黄斑部的血管和神经元变化相互影响。