The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The influences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial efficacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These findings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.

装载了利多卡因氯化物的纳米粒子的发展令人鼓舞，可以用于伤口愈合，腹部疼痛管理的生物材料。当前的工作提出了基于氯化利多卡因（LCH）（麻醉药）的多粘菌素（PMN）/乙二醇（GLY）负载的伤口敷料的成分。LCH纳米复合材料（LCH @ PMN / GLY）是通过PMN / GLY基质中的LCH氧化物溶液制备的。检查了不同实验限制对PMN / GLY纳米颗粒形成的影响。通过高分辨率扫描电子显微镜（HR-SEM）评估了PMN / GLY和LCH @ PMN / GLY纳米颗粒的大小。此外，还开发了PMN / GLY和LCH @ PMN / GLY的抗菌功效，用于革兰氏阳性和阴性微生物。而且，我们检查了小鼠模型在20天内形成的皮肤伤口的体内愈合情况。与未处理的伤口相比，在LCH @ PMN / GLY处理的伤口中感觉到快速愈合，损伤较小。这些发现表明，在动物模型的重症监护病房（ICU）管理中，基于LCH @ PMN / GLY的绷带材料可能是潜在的创新生物材料，可用于组织修复，植入和护理，用于腹部疼痛切口的伤口愈合。