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In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

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Abstract

The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The influences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial efficacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These findings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.

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Authors and Affiliations

  1. Emergency Intensive Care Unit, Wenling First People’s Hospital, Wenling, 317500, China

    Zhenfei Pan, Jinqiang Zhu, Yi Mao, Yamei Shao & Lili Chen

  2. Cerebrovascular Center, Wenling First People’s Hospital, Wenling, 317500, China

    Zhenzhen Jiang

  3. Department of Urology and Anorectal Surgery, the First People’s Hospital of Wenling, Wenling, 317500, China

    Wei Wu

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Contributions

ZP, JZ, and YM assisted with NP synthesis and characterization; ZJ, and YS assisted with molecular and biochemical analysis; WW assisted with data curation, formal analysis, and validation; LC assisted with supervised the research.

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Correspondence to Lili Chen.

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All animal experiments were approved by the Ethics Committee of the Emergency Intensive Care Unit, Wenling First People's Hospital, Wenling 317500, China in accordance with the guidelines on animal care and use (File No: 2019-10).

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Pan, Z., Zhu, J., Mao, Y. et al. In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit. J Polym Environ 29, 3732–3743 (2021). https://doi.org/10.1007/s10924-021-02093-7

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