Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.

作为骨骼再生和组织工程的骨移植替代品，可生物降解材料受到了极大的关注。然而，它们的低机械性能仍然是在承重应用中使用的主要挑战。在这里，我们开发了一种机械增强的复合支架，其中包含粘合剂levan作为烧结的羟基磷灰石（sHAp）的粘合剂，然后研究了复合支架的机械性能和热性能。我们发现sHAp-levan复合支架表现出显着增强的机械强度，与聚甲基丙烯酸甲酯（PMMA）骨水泥相似。这种复合支架可用作骨再生和组织工程的有前途的骨移植物。