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Evaluation of Mechanical and Thermal Properties of Hydroxyapatite-levan Composite Bone Graft
Biotechnology and Bioprocess Engineering ( IF 2.5 ) Pub Date : 2021-04-13 , DOI: 10.1007/s12257-020-0094-6
Younghoon Song , Kye Il Joo , Jeong Hyun Seo

Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.



中文翻译:

羟基磷灰石-莱文复合骨接枝力学性能和热学性能的评价

作为骨骼再生和组织工程的骨移植替代品,可生物降解材料受到了极大的关注。然而,它们的低机械性能仍然是在承重应用中使用的主要挑战。在这里,我们开发了一种机械增强的复合支架,其中包含粘合剂levan作为烧结的羟基磷灰石(sHAp)的粘合剂,然后研究了复合支架的机械性能和热性能。我们发现sHAp-levan复合支架表现出显着增强的机械强度,与聚甲基丙烯酸甲酯(PMMA)骨水泥相似。这种复合支架可用作骨再生和组织工程的有前途的骨移植物。

更新日期:2021-04-13
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