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Evaluation of Mechanical and Thermal Properties of Hydroxyapatite-levan Composite Bone Graft

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Abstract

Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.

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Acknowldgement

This study was supported by the 2018 Yeungnam University Research Grant and by the Human Resources Program in Energy Technology of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) granted financial resource from the Ministry of Trade, Industry & Energy, Korea (No. 20174030201760).

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Authors and Affiliations

  1. School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Korea

    Younghoon Song & Jeong Hyun Seo

  2. Division of Chemical Engineering and Materials Science, Ewha Womans University, Seoul, 03760, Korea

    Kye Joo II

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  1. Younghoon Song
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Correspondence to Kye Joo II or Jeong Hyun Seo.

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Song, Y., Joo, K. & Seo, J.H. Evaluation of Mechanical and Thermal Properties of Hydroxyapatite-levan Composite Bone Graft. Biotechnol Bioproc E 26, 201–207 (2021). https://doi.org/10.1007/s12257-020-0094-6

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  • DOI: https://doi.org/10.1007/s12257-020-0094-6

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