Abstract—

Lactobacillus fermentum 39 is a well-known probiotic strain, which is widely used for production of pharmacopoeial probiotic preparations, dietary supplements, and foodstuffs enriched with probiotic microorganisms. In the course of analysis by transmission electron microscopy, the cell morphology was studied, biochemical properties of the strain and strain-specific characteristics of sugar metabolism were thoroughly analyzed, its full genome was sequenced, and the cluster of genes responsible for exopolysaccharide synthesis was characterized. The cells of Lactobacillus fermentum 39 were shown to be capable of adsorbing rotavirus particles, which allows us to substantiate a new aspect of application of probiotics, including this strain, in acute gastroenteritis caused by human rotaviruses.

中文翻译：

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益生菌发酵乳杆菌39：生化特性，基因组特征和抗病毒活性

摘要—

发酵乳杆菌39是众所周知的益生菌菌株，其广泛用于生产药典益生菌制剂，膳食补充剂和富含益生菌微生物的食品。在透射电子显微镜分析过程中，研究了细胞的形态，彻底分析了菌株的生化特性和糖代谢的菌株特异性特征，对其全基因组进行了测序，并对负责胞外多糖合成的基因簇进行了表征。已显示发酵乳杆菌39的细胞能够吸附轮状病毒颗粒，这使我们能够证实益生菌（包括该菌株）在由人轮状病毒引起的急性胃肠炎中的新应用。