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The Probiotic Strain Lactobacillus fermentum 39: Biochemical Properties, Genomic Features, and Antiviral Activity

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Abstract—

Lactobacillus fermentum 39 is a well-known probiotic strain, which is widely used for production of pharmacopoeial probiotic preparations, dietary supplements, and foodstuffs enriched with probiotic microorganisms. In the course of analysis by transmission electron microscopy, the cell morphology was studied, biochemical properties of the strain and strain-specific characteristics of sugar metabolism were thoroughly analyzed, its full genome was sequenced, and the cluster of genes responsible for exopolysaccharide synthesis was characterized. The cells of Lactobacillus fermentum 39 were shown to be capable of adsorbing rotavirus particles, which allows us to substantiate a new aspect of application of probiotics, including this strain, in acute gastroenteritis caused by human rotaviruses.

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Authors and Affiliations

  1. Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology, 603950, Nizhny Novgorod, Russia

    I. V. Soloveva, N. A. Novikova, A. G. Tochilina, I. V. Belova, A. Yu. Kashnikov, T. A. Sashina, V. A. Zhirnov & S. B. Molodtsova

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  1. I. V. Soloveva
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  2. N. A. Novikova
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  3. A. G. Tochilina
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  4. I. V. Belova
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  5. A. Yu. Kashnikov
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Correspondence to A. G. Tochilina.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by E. Makeeva

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Soloveva, I.V., Novikova, N.A., Tochilina, A.G. et al. The Probiotic Strain Lactobacillus fermentum 39: Biochemical Properties, Genomic Features, and Antiviral Activity. Microbiology 90, 219–225 (2021). https://doi.org/10.1134/S0026261721020132

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