Radioembolization (RE) is a treatment for patients with liver cancer, one of the leading cause of cancer-related deaths worldwide. RE consists of the transcatheter intraarterial infusion of radioactive microspheres, which are injected at the hepatic artery level and are transported in the bloodstream, aiming to target tumors and spare healthy liver parenchyma. In paving the way towards a computer platform that allows for a treatment planning based on computational fluid dynamics (CFD) simulations, the current simulation (model preprocess, model solving, model postprocess) times (of the order of days) make the CFD-based assessment non-viable. One of the approaches to reduce the simulation time includes the reduction in size of the simulated truncated hepatic artery. In this study, we analyze for three patient-specific hepatic arteries the impact of reducing the geometry of the hepatic artery on the simulation time. Results show that geometries can be efficiently shortened without impacting greatly on the microsphere distribution.

中文翻译：

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放射栓塞的CFD模拟：关于肝动脉截断影响的概念验证研究

放射栓塞（RE）是一种治疗肝癌患者的方法，肝癌是全球范围内与癌症相关的死亡的主要原因之一。RE由经导管的放射性微球经动脉内输注组成，放射性微球在肝动脉水平注射并在血流中运输，旨在靶向肿瘤并节省健康的肝实质。在为允许基于计算流体动力学（CFD）模拟进行治疗计划的计算机平台铺平道路时，当前的模拟（模型预处理，模型求解，模型后处理）时间（数天左右）使基于CFD评估不可行。减少模拟时间的方法之一包括减小模拟的截短的肝动脉的尺寸。在这项研究中，我们针对三个患者特定的肝动脉分析了减少肝动脉几何形状对模拟时间的影响。结果表明，可以有效缩短几何形状，而不会对微球的分布产生很大影响。