A novel coordination polymer containing Mn(II) ions as nodes was prepared by the hydrothermal method, and its chemical formula is {[Mn₂(L)(hfpd)(H₂O)]·1.75H₂O}_n (1) (L = 4,4′-bis(imidazol-1-yl)-biphenyl and H₄hfpd = 4,4′-(hexafluoroisopropylidene)diphthalic acid). It was then used for evaluation the relationship with the Endometriosis (EMs). The activation for the estrogen receptor relative expression on the surface of endometrial cell was detected through the real time RT-PCR, and the results showed that complex 1 could obviously decreased the estrogen receptor over expression on the endometrial cell surface dose dependently. The immune function of the macrophages under the endometrial cells were determined by Western blot, the data indicated that complex 1 exerts the excellent treatment activity via activating the autophagy in macrophages. Molecular docking simulations reveal that the origin of the biological activity is from the carboxyl functional groups on the complex.

通过水热法制备了一种新型的以Mn（II）离子为节点的配位聚合物，其化学式为{[Mn ₂（L）（hfpd）（H ₂ O）]·1.75H ₂ O} _n（1） （L ＝ 4，4′-双（咪唑-1-基）联苯，H ₄ hfpd ＝ 4，4′-（六氟异亚丙基）二邻苯二甲酸）。然后将其用于评估与子宫内膜异位症（EMs）的关系。通过实时RT-PCR检测子宫内膜细胞表面雌激素受体相对表达的激活，结果表明复合物1可以明显降低雌激素受体在子宫内膜细胞表面过度表达的剂量依赖性。通过Western印迹确定巨噬细胞在子宫内膜细胞下的免疫功能，数据表明复合物1通过激活巨噬细胞中的自噬发挥优异的治疗活性。分子对接模拟表明，生物活性的起源是来自复合物上的羧基官能团。