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A Mn(II)-Coordination Polymer: Treatment Activity on the Endometriosis and Mechanism Exploration

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Abstract

A novel coordination polymer containing Mn(II) ions as nodes was prepared by the hydrothermal method, and its chemical formula is {[Mn2(L)(hfpd)(H2O)]·1.75H2O}n (1) (L = 4,4′-bis(imidazol-1-yl)-biphenyl and H4hfpd = 4,4′-(hexafluoroisopropylidene)diphthalic acid). It was then used for evaluation the relationship with the Endometriosis (EMs). The activation for the estrogen receptor relative expression on the surface of endometrial cell was detected through the real time RT-PCR, and the results showed that complex 1 could obviously decreased the estrogen receptor over expression on the endometrial cell surface dose dependently. The immune function of the macrophages under the endometrial cells were determined by Western blot, the data indicated that complex 1 exerts the excellent treatment activity via activating the autophagy in macrophages. Molecular docking simulations reveal that the origin of the biological activity is from the carboxyl functional groups on the complex.

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Authors and Affiliations

  1. Department of Gynaecology, The Third Hospital of Ji’nan, Ji’nan, Shandong, China

    Yun-Xia Xue

  2. Department of Obstetrics, The Third Hospital of Ji’nan, Ji’nan, Shandong, China

    Chun-Xiang Lou

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  1. Yun-Xia Xue
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  2. Chun-Xiang Lou
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Correspondence to Yun-Xia Xue.

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Xue, YX., Lou, CX. A Mn(II)-Coordination Polymer: Treatment Activity on the Endometriosis and Mechanism Exploration. J Clust Sci 33, 1353–1360 (2022). https://doi.org/10.1007/s10876-021-02058-9

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  • DOI: https://doi.org/10.1007/s10876-021-02058-9

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