A bone biopsy is still considered the gold standard for diagnosis of renal osteodystrophy. It allows to measure both static and dynamic parameters of bone remodeling and is the only method able to evaluate mineralization and allows analysis of both cortical and trabecular bone. Although bone volume can be measured indirectly by dual-energy X-ray absorptiometry, mineralization defects, bone metal deposits, cellular number/activity, and even turnover abnormalities are difficult to determine by techniques other than qualitative bone histomorphometry. In this review, we evaluate the role of bone biopsy in the clinical practice.

中文翻译：

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骨活检在 CKD-MBD 管理中的作用

骨活检仍被认为是诊断肾性骨营养不良的金标准。它允许测量骨重建的静态和动态参数，是唯一能够评估矿化并允许分析皮质骨和小梁骨的方法。虽然骨量可以通过双能 X 射线吸收测定法间接测量，但矿化缺陷、骨金属沉积、细胞数量/活动，甚至周转异常都难以通过定性骨组织形态测定法以外的技术来确定。在这篇综述中，我们评估了骨活检在临床实践中的作用。