Infertility is regarded as a global health problem affecting 8–12% of couples. Male factors are regarded as the main cause of infertility in 40% of infertile couples and contribute to this condition in combination with female factors in another 20% of cases. Abnormal sperm parameters such as oligospermia, asthenospermia, and teratozoospermia result in male factor infertility. Several studies have shown the deteriorative impact of heavy metals on sperm parameters and fertility in human subjects or animal models. Other studies have pointed to the role of antioxidants in counteracting the detrimental effects of heavy metals. In the currents study, we summarize the main outcomes of studies that assessed the counteracting impacts of heavy metal and antioxidants on male fertility. Based on the provided data from animal studies, it seems rational to administrate appropriate antioxidants in persons who suffer from abnormal sperm parameters and infertility due to exposure to toxic elements. Yet, further human studies are needed to approve the beneficial effects of these antioxidants.

不孕症被认为是影响 8-12% 夫妇的全球健康问题。男性因素被认为是 40% 的不孕夫妇不孕的主要原因，并且在另外 20% 的情况下与女性因素一起导致这种情况。精子参数异常，如少精子症、弱精子症和畸形精子症会导致男性因素不育。几项研究表明重金属对人类受试者或动物模型的精子参数和生育能力的恶化影响。其他研究指出抗氧化剂在抵消重金属的有害影响方面的作用。在当前的研究中，我们总结了评估重金属和抗氧化剂对男性生育能力的抵消影响的研究的主要结果。根据提供的动物研究数据，对因接触有毒元素而导致精子参数异常和不育的人服用适当的抗氧化剂似乎是合理的。然而，需要进一步的人体研究来证实这些抗氧化剂的有益作用。