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Counteracting effects of heavy metals and antioxidants on male fertility

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Abstract

Infertility is regarded as a global health problem affecting 8–12% of couples. Male factors are regarded as the main cause of infertility in 40% of infertile couples and contribute to this condition in combination with female factors in another 20% of cases. Abnormal sperm parameters such as oligospermia, asthenospermia, and teratozoospermia result in male factor infertility. Several studies have shown the deteriorative impact of heavy metals on sperm parameters and fertility in human subjects or animal models. Other studies have pointed to the role of antioxidants in counteracting the detrimental effects of heavy metals. In the currents study, we summarize the main outcomes of studies that assessed the counteracting impacts of heavy metal and antioxidants on male fertility. Based on the provided data from animal studies, it seems rational to administrate appropriate antioxidants in persons who suffer from abnormal sperm parameters and infertility due to exposure to toxic elements. Yet, further human studies are needed to approve the beneficial effects of these antioxidants.

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Acknowledgements

This study was financially supported by Shahid Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  2. Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

    Hamed Shoorei

  3. School of Advancement, Centennial College, Ashtonbee Campus, Toronto, ON, Canada

    Mahdi Mohaqiq

  4. Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA

    Mahdi Mohaqiq

  5. Faculty of Medicine, Department of Anatomy, Tarbiat Modares University, Tehran, Iran

    Moloud Tahmasebi

  6. Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mohammad Seify

  7. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

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  1. Soudeh Ghafouri-Fard
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Ghafouri-Fard, S., Shoorei, H., Mohaqiq, M. et al. Counteracting effects of heavy metals and antioxidants on male fertility. Biometals 34, 439–491 (2021). https://doi.org/10.1007/s10534-021-00297-x

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