The oxidation of rabeprazole sulfide is a key step in the synthesis of rabeprazole, a drug for the treatment of stomach acid-related disorders. The current rabeprazole production process adopts one pot batch process, which has low reaction efficiency and poor stability. A continuous process can greatly improve the production efficiency and solve the above problems. Therefore, the reaction parameters of rabeprazole in microreactor were explored through laboratory experiments to explore the possibility of continuous production of rabeprazole. Rabeprazole sodium was synthesized by using rabeprazole thioether as a raw material and sodium hypochlorite solution as the oxidant. Oxidation, quenching, acid-base regulation and extraction were completed continuously in the microreactor. Rabeprazole solution with a purity of 98.78% (±0.13%) can be obtained continuously in 56 s, whereas intermittent production lasted for at least 2 h. Thus, the microreactor can effectively improve the oxidation synthesis efficiency of rabeprazole, and provide reference for the realization of other reactions in the microreactor.

中文翻译：

---

连续流微反应器在雷贝拉唑合成及萃取中的应用

雷贝拉唑硫化物的氧化是雷贝拉唑合成的关键步骤，雷贝拉唑是一种治疗胃酸相关疾病的药物。目前雷贝拉唑的生产工艺采用一锅法，反应效率低，稳定性差。连续过程可以大大提高生产效率并解决上述问题。因此，通过实验室实验探索了雷贝拉唑在微反应器中的反应参数，以探讨雷贝拉唑连续生产的可能性。以雷贝拉唑硫醚为原料，次氯酸钠溶液为氧化剂，合成雷贝拉唑钠。在微反应器中连续完成氧化，淬灭，酸碱调节和萃取。雷贝拉唑溶液，纯度为98.78％（±0。在56 s内可以连续获得13％），而间歇性生产至少持续2 h。因此，微反应器可有效提高雷贝拉唑的氧化合成效率，为实现微反应器中的其他反应提供参考。