Abstract
The oxidation of rabeprazole sulfide is a key step in the synthesis of rabeprazole, a drug for the treatment of stomach acid-related disorders. The current rabeprazole production process adopts one pot batch process, which has low reaction efficiency and poor stability. A continuous process can greatly improve the production efficiency and solve the above problems. Therefore, the reaction parameters of rabeprazole in microreactor were explored through laboratory experiments to explore the possibility of continuous production of rabeprazole. Rabeprazole sodium was synthesized by using rabeprazole thioether as a raw material and sodium hypochlorite solution as the oxidant. Oxidation, quenching, acid-base regulation and extraction were completed continuously in the microreactor. Rabeprazole solution with a purity of 98.78% (±0.13%) can be obtained continuously in 56 s, whereas intermittent production lasted for at least 2 h. Thus, the microreactor can effectively improve the oxidation synthesis efficiency of rabeprazole, and provide reference for the realization of other reactions in the microreactor.
Funding source: Shandong Province Taishan Scholar engineering under special funding Foundations
Funding source: Shandong Provincial Natural Science Foundation
Award Identifier / Grant number: ZR2020MB122
Funding source: Shandong Provincial Primary Research & Department Plan of China
Award Identifier / Grant number: 2019GSF109009
Acknowledgments
Financial support from Shandong Province Taishan Scholar engineering under special funding Foundations, Shandong Provincial Primary Research & Department Plan of China (no. 2019GSF109009) and Shandong Provincial Natural Science Foundation (no. ZR2020MB122) are sincerely appreciated by the authors during the course of this work.
Author contributions: All authors contributed to the paper and accepted responsibility for the entire content.
Research funding: Shandong Province Taishan Scholar engineering under special funding Foundations; Shandong Provincial Natural Science Foundation (ZR2020MB122); Shandong Provincial Primary Research & Department Plan of China (2019GSF109009).
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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