The relationship of intrauterine phthalate exposure with gestational metabolic syndrome (GMS) parameters is inconsistently reported. We performed a systematic review to evaluate the association between prenatal phthalate exposure and GMS parameters. A literature search was performed in three databases. According to the defined PECOS statement, eligible studies were identified. The method and result for each study was qualitatively summarized with great emphasis on study design and exposure assessment. Fourteen studies were included in the present systematic review. Two studies used one-spot serum sample for evaluation of phthalate exposure, while others used 1–4 urine samples. Concentrations of phthalate metabolites varied substantially, and the levels in serum were greatly lower than those in urine. These studies observed no interstudy or intrastudy consistency for association between phthalates and GMS in pregnant women cross-sectionally or longitudinally, regardless of phthalates species or GMS indicator. Most reported associations were not significantly different from null result. Besides, positive and negative relationships also existed. The current epidemiological data do not support the hypothesis that prenatal exposure to phthalates increases GMS risk.

宫内邻苯二甲酸盐暴露与妊娠代谢综合征 (GMS) 参数之间的关系报道不一致。我们进行了系统评价，以评估产前邻苯二甲酸盐暴露与 GMS 参数之间的关联。在三个数据库中进行了文献检索。根据定义的 PECOS 声明，确定了合格的研究。对每项研究的方法和结果进行了定性总结，重点关注研究设计和暴露评估。本系统评价纳入了十四项研究。两项研究使用单点血清样本来评估邻苯二甲酸盐暴露，而其他研究则使用 1-4 个尿液样本。邻苯二甲酸酯代谢物的浓度变化很大，血清中的水平大大低于尿液中的水平。这些研究没有观察到孕妇中邻苯二甲酸盐与 GMS 之间关联的横向或纵向一致性，无论邻苯二甲酸盐种类或 GMS 指标如何。大多数报告的关联与无效结果没有显着差异。此外，还存在积极和消极的关系。目前的流行病学数据并不支持产前接触邻苯二甲酸盐会增加 GMS 风险的假设。