Nausea and vomiting are common for runners during ultramarathons and often contribute to non-finishes. We aimed to determine the efficacy of ondansetron, a commonly used antiemetic, to treat nausea and vomiting in runners during an ultramarathon. Runners who had a previous history of frequent nausea or vomiting during races and entered in 160, 80, and 55 km ultramarathons in 2018 and 2019 were randomized in a double-blind fashion to 4 mg ondansetron or placebo capsules to use if they developed nausea or vomiting during the race with the ability to take three additional doses. Study participants completed a post-race online survey to assess medication use and efficacy. Of 62 study participants, 31 took either ondansetron (20) or placebo (11). In this small study, there were no group differences in those reporting any improvement in nausea and vomiting (p = 0.26) or in the amount of improvement (p = 0.15). We found no evidence that ondansetron capsules improve nausea and vomiting during ultramarathons.

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口服恩丹西酮治疗与超马拉松相关的恶心的研究：TOO FUN研究

在超马拉松比赛中，恶心和呕吐对于跑步者来说很常见，并且经常导致未完成。我们的目的是确定常用的止吐药ondansetron在超级马拉松期间治疗跑步者恶心和呕吐的功效。曾在比赛中经常出现恶心或呕吐史的跑步者，并且在2018年和2019年参加了160、80和55公里的超级马拉松比赛，以双盲方式随机分为4毫克恩丹西酮或安慰剂胶囊，如果他们出现恶心或呕吐，可以使用在比赛中呕吐，可以补充三剂。研究参与者完成了赛后在线调查，以评估药物的使用和疗效。在62位研究参与者中，有31位服用了恩丹西酮（20）或安慰剂（11）。在这个小书房里p = 0.26）或改进量（p = 0.15）。我们没有发现证据表明恩丹西酮胶囊可改善超级马拉松期间的恶心和呕吐。