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Photoactivatable CaMKII: Rewiring the Brain, One Synapse at a Time
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2021-03-02 , DOI: 10.1016/j.tins.2021.02.004 Christine E Gee 1 , Thomas G Oertner 1
中文翻译:
可光活化的CaMKII:重新连接大脑,一次突触
更新日期:2021-03-23
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2021-03-02 , DOI: 10.1016/j.tins.2021.02.004 Christine E Gee 1 , Thomas G Oertner 1
Affiliation
A recent article by Shibata et al. introduces the engineered photoactivatable enzyme paCaMKII. Activation of this new tool is sufficient to induce long-term potentiation (LTP) of hippocampal synapses in slice culture and in intact animals, thereby expanding the existing toolkit for light-induced modification of brain connectivity at the synaptic level.
中文翻译:
可光活化的CaMKII:重新连接大脑,一次突触
Shibata等人的最新文章。介绍了工程化的光活化酶paCaMKII。激活此新工具足以在切片培养和完整动物中诱导海马突触的长期增强(LTP),从而扩展了现有的工具包,用于在突触水平上光诱导的大脑连接修饰。