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Photoactivatable CaMKII: Rewiring the Brain, One Synapse at a Time

https://doi.org/10.1016/j.tins.2021.02.004Get rights and content

A recent article by Shibata et al. introduces the engineered photoactivatable enzyme paCaMKII. Activation of this new tool is sufficient to induce long-term potentiation (LTP) of hippocampal synapses in slice culture and in intact animals, thereby expanding the existing toolkit for light-induced modification of brain connectivity at the synaptic level.

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Acknowledgments

We thank members of the Oertner laboratory for useful comments.

Declaration of Interests

The authors declare no competing interests in relation to this work.

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