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Newly Developed N -butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery
Macromolecular Research ( IF 2.8 ) Pub Date : 2021-03-02 , DOI: 10.1007/s13233-021-9022-7
Young Chul Cho , Wooram Park , Jeon Min Kang , Dae Sung Ryu , Yubeen Park , Jae-Won Seo , Young Gook Koh , Jung-Hoon Park , Ji Hoon Shin

N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases.



中文翻译:

新开发的用于动脉栓塞的氰基丙烯酸正丁酯(EG胶):兔肾动脉的临床前研究

Ñ丁基氰基丙烯酸酯(NBCA)胶已经被广泛用于各种血管病变范围从急性内脏出血到动静脉畸形的血管内管理。在这里,我们调查了新开发的NBCA胶(EG胶)与常规胶(Histoacryl)相比在兔肾动脉中经导管动脉栓塞(TAE)的有效性和安全性。与Histoacryl相比,EG胶具有相似的物理性能和栓​​塞功效。在两组中,在所有兔子中均观察到血管壁中的坏死性病变,没有显着差异。基于这些结果,我们认为EG胶可能是治疗各种疾病的有希望的替代栓塞材料。

更新日期:2021-03-02
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