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Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

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Abstract

N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases.

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Author notes

  1. Y. C. C. and W. P. contributed equally to this work and are the co-first authors.

Authors and Affiliations

  1. Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea

    Young Chul Cho & Ji Hoon Shin

  2. Department of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi, 14662, Korea

    Wooram Park

  3. Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea

    Jeon Min Kang, Dae Sung Ryu, Yubeen Park & Jung-Hoon Park

  4. R&D Center, ENGAIN Co., Ltd., Korea Bio Park BLD C 2F, 700 Daewangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi, 13488, Korea

    Jae-Won Seo & Young Gook Koh

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  1. Young Chul Cho
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Contributions

Author contributions: Conceptualization, Jae-Won Seo, Jung-Hoon Park, and Ji Hoon Shin; Data curation, Yubeen Park; Formal analysis, Young Chul Cho, Jeon Min Kang, Dae Sung Ryu and Yubeen Park; Funding acquisition, Wooram Park, Jung-Hoon Park, and Ji Hoon Shin; Investigation, Young Chul Cho and Wooram Park; Methodology, Jeon Min Kang, Dae Sung Ryu, and Young Gook Koh; Resources, Jae-Won Seo and Young Gook Koh; Supervision, Jung-Hoon Park and Ji Hoon Shin; Writing — original draft, Young Chul Cho and Wooram Park; Writing — review & editing, Jung-Hoon Park and Ji Hoon Shin.

Corresponding authors

Correspondence to Jung-Hoon Park or Ji Hoon Shin.

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Acknowledgments: This study was supported by a grant (2014-312) from the Asan Institute for Life Sciences, Asan Medical Center (Seoul, Korea) and the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (202012D21-02).

The image from this article is used as the cover image of the Volume 29, Issue 2.

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Cho, Y.C., Park, W., Kang, J.M. et al. Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery. Macromol. Res. 29, 178–184 (2021). https://doi.org/10.1007/s13233-021-9022-7

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