Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study,Journal of Cardiovascular Translational Research

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Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study
Journal of Cardiovascular Translational Research ( IF 2.4 ) Pub Date : 2021-03-01 , DOI: 10.1007/s12265-021-10106-y
Naja Dam Mygind _{1,

2} , Signe Holm Nielsen _{3,

4} , Marie Mide Michelsen ₁ , Adam Pena ₅ , Daria Frestad Bechsgaard ₆ , Elena Suhrs ₁ , Kira Bang Bove ₁ , Federica Genovese ₃ , Henning Bay Nielsen ₇ , Morten Karsdal ₃ , Niels Vejlstrup ₂ , Eva Prescott ₁ , Jens Kastrup ₂

Affiliation

Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r² = 0.38, p<0.001 and r² = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.

Graphical abstract

中文翻译：

患有心绞痛和弥漫性心肌纤维化的女性加速蛋白多糖重塑：iPOWER 研究

心绞痛和非阻塞性冠状动脉疾病 (CAD) 的预后不良，可能是由于弥漫性心肌纤维化 (DMF)。在 DMF 中，蛋白聚糖双糖链蛋白聚糖和多功能蛋白聚糖被基质金属蛋白酶主动重塑。我们调查了患有心绞痛的女性中的 biglycan 和 versican，并通过心脏磁共振 (CMR) 评估了可能的 DMF。包括 71 名患有心绞痛且无阻塞性 CAD 的女性。无症状的女性作为对照。测量了 Versican 和 biglycan，并进行了 CMR 测量细胞外体积。与对照组相比，有症状女性的 Biglycan 和 versican 水平更高；31.4 ng/mL vs. 16.4 ng/mL ( p < 0.001) 和 2.1 ng/mL vs. 1.8 ng/mL ( p < 0.001)，与细胞外体积 ( r² = 0.38，p<0.001，r ² = 0.26，p = 0.015）。与对照组相比，女性心绞痛中双糖链蛋白聚糖和多功能蛋白聚糖的更替增加，并且与细胞外体积相关，这支持了无阻塞性 CAD 的心绞痛与纤维化重塑之间的联系。

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更新日期：2021-03-01

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