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Structure-rheology elucidation of human blood via SPP framework and TEVP modeling
Korea-Australia Rheology Journal ( IF 2.2 ) Pub Date : 2021-02-27 , DOI: 10.1007/s13367-021-0005-1
Matthew Armstrong , Jeff Baker , Jesse Trump , Erin Milner , J. Kenneth Wickiser , Kenneth Cameron , Nick Clark , Kaitlyn Schwarting , Thomas Brown , Dorian Bailey , Corey James , Chi Nguyen , Trevor Corrigan

Recent work modeling the rheological behavior of human blood indicates that it has all the hallmark features of a complex material, including shear-thinning, viscoelastic behavior, a yield stress, and thixotropy. After decades of modeling steady state blood data, and the development of simple steady state models, like the Casson and Herschel-Bulkley the advancement and evolution of blood modeling to incorporate more thixo-elasto-visco-plastic (TEVP) features to accurately capture transient flow has renewed interest. With recently collected steady state and oscillatory shear flow rheological data from a DHR-3 using human blood, we show modeling efforts with a contemporary thixo-elasto-visco-plastic (TEVP) model. Best fit rheological model parameters are used to determine values for normal, healthy blood and corroborate correlations from literature. Series of physical processes (SPP) analysis is incorporated to illustrate how mechanical properties are tied to the transient, evolving microstructure of human blood and physiological parameters. Using LAOS data predictions of the structure parameter, λ is compared, and correlated with the transient elastic modulus, G t .



中文翻译:

通过SPP框架和TEVP建模来阐明人血的结构流变学

对人体血液流变行为进行建模的最新工作表明,它具有复杂材料的所有标志性特征,包括剪切稀化,粘弹性行为,屈服应力和触变性。经过数十年的稳态血液数据建模,以及简单的稳态模型(例如Casson和Herschel-Bulkley)的发展,血液建模的进步和发展,整合了更多的触变性-弹-粘塑性(TEVP)功能来准确地捕获瞬态流量重新引起了人们的兴趣。利用最近从人血DHR-3收集的稳态和振荡剪切流变流变数据,我们展示了使用现代触变弹塑性粘塑性(TEVP)模型进行的建模工作。最佳拟合流变模型参数用于确定正常,健康血液的值,并根据文献确定相关性。结合了一系列物理过程(SPP)分析,以说明机械性能如何与人体血液的瞬态,不断发展的微观结构和生理参数联系在一起。使用结构参数的LAOS数据预测,λ进行比较,并与瞬时弹性模量,相关ģ '

更新日期:2021-02-28
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