Abstract

We consider methods for modeling and develop a unified approach to constructing mathematical models of the kinetics of radiopharmaceuticals with iodine isotopes in the human body during diagnostic and therapeutic procedures of nuclear medicine. Various techniques for identifying the model parameters based on quantitative data of radionuclide studies of the functional state of organs are proposed. The results of pharmacokinetic modeling in radionuclide diagnostics of the liver, kidneys, and thyroid using iodine-containing radiopharmaceuticals are presented and analyzed. The features and results of modeling and dosimetric planning of thyroid radioiodine therapy are also discussed.

中文翻译：

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核医学问题中含碘放射性示踪剂动力学的数学建模

摘要

我们考虑了建模方法，并开发了一种统一的方法来构建核医学的诊断和治疗程序中人体中带有碘同位素的放射性药物动力学的数学模型。提出了各种基于放射性核素对器官功能状态的研究的定量数据来识别模型参数的技术。介绍并分析了使用含碘放射性药物对肝脏，肾脏和甲状腺进行放射性核素诊断的药代动力学建模结果。还讨论了甲状腺放射性碘疗法的建模和剂量规划的功能和结果。