Abstract

New copolymers of methyl acrylate with 1-vinylimidazole, 1-vinyl-1,2,4-triazole, and 4-vinyl-1,2,3-triazole are synthesized by radical copolymerization. It is shown that the reactivity ratios for methyl acrylate and 1-vinylimidazole are 0.83 ± 0.09 and 0.25 ± 0.02, for methyl acrylate and 1-vinyl-1,2,4-triazole are 1.0 ± 0.04 and 0.27 ± 0.01, and for methyl acrylate and (4-vinyl-1Н-1,2,3-triazolyl)-methyl pivalate are 0.56 ± 0.03 and 2.90 ± 0.20, respectively. The behavior of the copolymers in aqueous media and their thermoresponsive properties are studied by potentiometric titration and dynamic light scattering. Copolymer macromolecules occur in aqueous solutions in the form of large associates the fraction of which increases upon heating; in some cases, an insoluble phase is formed. It is found that the copolymers with the grafted oligopropylamine moieties containing N-vinylazole units can interact with the DNA oligonucleotide, stimulating their research as agents for the delivery of nucleic acids to living cells.

中文翻译：

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丙烯酸甲酯和乙烯基唑的共聚物：合成，热不稳定性和多胺链的接枝

摘要

通过自由基共聚合成丙烯酸甲酯与1-乙烯基咪唑，1-乙烯基-1,2,4-三唑和4-乙烯基-1,2,3-三唑的新共聚物。结果表明，丙烯酸甲酯和1-乙烯基咪唑的反应性比为0.83±0.09和0.25±0.02，丙烯酸甲酯和1-乙烯基-1,2,4-三唑的反应性比为1.0±0.04和0.27±0.01，而甲基丙烯酸酯和（4-乙烯基-1_-1,1,2,3-三唑基）-新戊酸甲酯分别为0.56±0.03和2.90±0.20。通过电位滴定和动态光散射研究了共聚物在水性介质中的行为及其热响应性能。共聚物大分子以大缔合物的形式存在于水溶液中，其部分随加热而增加；在某些情况下，形成不溶相。N-乙烯基唑单元可以与DNA寡核苷酸相互作用，从而刺激了它们作为将核酸输送到活细胞的试剂的研究。