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Copolymers of Methyl Acrylate and Vinylazoles: Synthesis, Thermolabile Properties, and Grafting of Polyamine Chains

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Abstract

New copolymers of methyl acrylate with 1-vinylimidazole, 1-vinyl-1,2,4-triazole, and 4-vinyl-1,2,3-triazole are synthesized by radical copolymerization. It is shown that the reactivity ratios for methyl acrylate and 1-vinylimidazole are 0.83 ± 0.09 and 0.25 ± 0.02, for methyl acrylate and 1-vinyl-1,2,4-triazole are 1.0 ± 0.04 and 0.27 ± 0.01, and for methyl acrylate and (4-vinyl-1Н-1,2,3-triazolyl)-methyl pivalate are 0.56 ± 0.03 and 2.90 ± 0.20, respectively. The behavior of the copolymers in aqueous media and their thermoresponsive properties are studied by potentiometric titration and dynamic light scattering. Copolymer macromolecules occur in aqueous solutions in the form of large associates the fraction of which increases upon heating; in some cases, an insoluble phase is formed. It is found that the copolymers with the grafted oligopropylamine moieties containing N-vinylazole units can interact with the DNA oligonucleotide, stimulating their research as agents for the delivery of nucleic acids to living cells.

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ACKNOWLEDGMENTS

We are grateful to the Shared Research Center Ultramicroanalysis for providing us with the equipment.

Funding

This work was supported by the Ministry of Science and Higher Education of the Russian Federation and the Russian Academy of Sciences (project no. АААА-А19-119100490016-4).

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Authors and Affiliations

  1. Limnological Institute, Siberian Branch, Russian Academy of Sciences, 664033, Irkutsk, Russia

    M. S. Strelova, E. N. Danilovtseva & V. V. Annenkov

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  1. M. S. Strelova
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  2. E. N. Danilovtseva
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  3. V. V. Annenkov
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Correspondence to M. S. Strelova.

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Translated by T. Soboleva

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Strelova, M.S., Danilovtseva, E.N. & Annenkov, V.V. Copolymers of Methyl Acrylate and Vinylazoles: Synthesis, Thermolabile Properties, and Grafting of Polyamine Chains. Polym. Sci. Ser. B 63, 41–51 (2021). https://doi.org/10.1134/S1560090421010061

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