The associations of vanadium exposure with hypertension risk in animal studies are inconsistent. Furthermore, epidemiologic studies on this topic are scarce. We aimed to assess the associations of vanadium exposure with hypertension prevalence and blood pressure levels in a general Chinese population. We measured urinary vanadium concentrations in 1867 participants to evaluate their internal exposure levels. The associations of urinary vanadium concentrations, categorized into quartiles or treated as continuous variables by logarithm transformation (log2), with hypertension prevalence and blood pressure levels were assessed by the multivariable logistic and linear regression models, respectively. We used the restricted cubic spline model to evaluate the dose-response relationship. Compared with the bottom quartile of vanadium, participants in the third and fourth quartile had an adjusted odds ratio of 2.04 (95% CI:1.40, 2.96) and 2.08 (95% CI:1.42, 3.06) for hypertension, with a linear dose-response relationship. The corresponding number for a doubling of vanadium concentrations was 1.25 (95% CI:1.12, 1.39). Besides, a doubling of vanadium concentrations was associated with a 0.66 (95% CI: 0.01, 1.31) and 0.90 (95% CI: 0.50, 1.31) mm Hg increased systolic and diastolic blood pressure level, respectively. Vanadium exposure was associated with increased hypertension prevalence and blood pressure levels. Prospective studies are needed to confirm our findings in other populations.

在动物研究中，钒暴露与高血压风险之间的关联是不一致的。此外，关于该主题的流行病学研究很少。我们的目的是评估普通人群中钒暴露与高血压患病率和血压水平的关系。我们测量了1867名参与者的尿中钒浓度，以评估其内部暴露水平。分别通过多变量对数和线性回归模型评估了尿中钒的浓度（分为四分位数或通过对数转换（log2）作为连续变量）与高血压患病率和血压水平的关联。我们使用受限三次样条模型来评估剂量反应关系。与钒的最低四分位数相比，第三和第四四分位数的参与者高血压的调整后优势比为2.04（95％CI：1.40，2.96）和2.08（95％CI：1.42，3.06），具有线性的剂量反应关系。钒浓度加倍的相应数字为1.25（95％CI：1.12，1.39）。此外，钒浓度加倍分别使收缩压和舒张压升高0.66（95％CI：0.01，1.31）和0.90（95％CI：0.50，1.31）mm Hg。钒暴露与高血压患病率和血压水平升高有关。需要进行前瞻性研究来证实我们在其他人群中的发现。钒浓度加倍的相应数字为1.25（95％CI：1.12，1.39）。此外，钒浓度增加一倍分别使收缩压和舒张压升高0.66（95％CI：0.01，1.31）和0.90（95％CI：0.50，1.31）mm Hg。钒暴露与高血压患病率和血压水平升高有关。需要进行前瞻性研究来证实我们在其他人群中的发现。钒浓度加倍的相应数字为1.25（95％CI：1.12，1.39）。此外，钒浓度增加一倍分别使收缩压和舒张压升高0.66（95％CI：0.01，1.31）和0.90（95％CI：0.50，1.31）mm Hg。钒暴露与高血压患病率和血压水平升高有关。需要进行前瞻性研究来证实我们在其他人群中的发现。