The first detailed study of vanadium (V) with hypertension and blood pressure.
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V was associated with increased hypertension prevalence and blood pressure levels.
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V was inversely associated with fasting glucose levels.
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The hypertensive effect of V might be independent of the insulin-mimetic effect.
Abstract
The associations of vanadium exposure with hypertension risk in animal studies are inconsistent. Furthermore, epidemiologic studies on this topic are scarce. We aimed to assess the associations of vanadium exposure with hypertension prevalence and blood pressure levels in a general Chinese population. We measured urinary vanadium concentrations in 1867 participants to evaluate their internal exposure levels. The associations of urinary vanadium concentrations, categorized into quartiles or treated as continuous variables by logarithm transformation (log2), with hypertension prevalence and blood pressure levels were assessed by the multivariable logistic and linear regression models, respectively. We used the restricted cubic spline model to evaluate the dose-response relationship. Compared with the bottom quartile of vanadium, participants in the third and fourth quartile had an adjusted odds ratio of 2.04 (95% CI:1.40, 2.96) and 2.08 (95% CI:1.42, 3.06) for hypertension, with a linear dose-response relationship. The corresponding number for a doubling of vanadium concentrations was 1.25 (95% CI:1.12, 1.39). Besides, a doubling of vanadium concentrations was associated with a 0.66 (95% CI: 0.01, 1.31) and 0.90 (95% CI: 0.50, 1.31) mm Hg increased systolic and diastolic blood pressure level, respectively. Vanadium exposure was associated with increased hypertension prevalence and blood pressure levels. Prospective studies are needed to confirm our findings in other populations.
