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Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells
Trends in Immunology ( IF 13.1 ) Pub Date : 2021-02-06 , DOI: 10.1016/j.it.2021.01.008
Peter L Wang 1 , Rafael S Czepielewski 1 , Gwendalyn J Randolph 1
Affiliation  

The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.



中文翻译:

感觉神经调节淋巴结细胞的转录动力学

神经系统在组织内稳态和炎症反应中起着重要作用。然而,神经对淋巴结 (LN) 的调节在很大程度上仍是未知的。黄等人。证明 LN 由独特的肽能伤害感受器支配,这些肽能伤害感受器向 LN 中的各种内皮、基质和免疫细胞类型发出信号。

更新日期:2021-02-25
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