Trends in Immunology

Trends in Immunology

Volume 42, Issue 3, March 2021, Pages 180-182
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Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

https://doi.org/10.1016/j.it.2021.01.008Get rights and content

The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.

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Acknowledgments

Work in the laboratory of G.J.R. is supported by NIH grants R37AI049653, R01DK119147, DP1DK126190, and a Synergy Award from the Rainin Foundation. P.L.W. received support from the Principles in Pulmonary Research training grant (T32 HL007317-41) and R.S.C. received support from the Lawrence C. Pakula, MD IBD Education & Innovation Fund (FA-2020-01-IBD-1).

Declaration of Interests

No interests are declared.

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