Interactions within mixtures of the phenothiazine drug promethazine hydrochloride (PMH) and cationic hydrotropes ortho-toluidine hydrochloride (o-TDH) and para-toluidine hydrochloride (p-TDH) were investigated at different ratios and temperatures via conductometry to understand various physicochemical properties. Critical micelle concentration (cmc) was less than values of cmc^id (cmc in ideal mixed system), indicating significant interaction among the studied constituents in solution mixtures. The cmc of pure PMH was also determined by measuring the surface tension for comparison. A variety of micellization thermodynamic parameters (Gibbs free energy [ΔG ⁰_m ], change in standard enthalpy [ΔG ⁰_m ], and change in entropy [ΔG ⁰_m ]) were computed using conductometry. The micellar mole fraction (X ^Rb₁ , X ^Rod₁ , and X ^id₁ ) of hydrotropes estimated by various theoretical models (Rubingh, Rodenas, and Motomura) was assessed, and the results showed a greater contribution of hydrotropes in mixed micelles along with their values increasing via an increase in mole fraction (α₁) of hydrotropes (o-TDH/p-TDH). Negative β values suggest extremely favorable attractive interaction/synergism, as declines occurred in the whole quantity of amphiphile used for the desired purpose, leading to a drop of expenditure along with ecological concern. Obtained activity coefficients (f₁ and f₂) were always beneath unity, meaning nonideality was found between PMH and o-TDH/p-TDH. Like the conductivity method, the UV-visible and FT-IR techniques also demonstrate the interaction between the PMH and o-TDH/p-TDH.

通过电导率法在不同比例和温度下研究了吩噻嗪药物盐酸异丙嗪（PMH）与阳离子水溶助长剂邻甲苯胺盐酸盐（o -TDH）和对甲苯胺盐酸盐（p -TDH）混合物之间的相互作用，以了解各种理化性质。临界胶束浓度（CMC）小于值CMC ^ID（CMC在理想混合体系），表明溶液的混合物所研究的组分之间相互作用显著。该CMC还通过测量表面张力来确定纯PMH的含量，以进行比较。各种胶束化热力学参数（吉布斯自由能[ΔG ⁰_米]，在标准焓变[ΔG ⁰_米]和在熵变[ΔG ⁰_米]），使用电导计算。评估了各种理论模型（Rubingh，Rodenas和Motomura）估算的水溶助长剂的胶束摩尔分数（X ^Rb ₁，X ^Rod ₁和X ^id ₁），结果表明水溶助长剂在混合胶束中的贡献更大。它们的值通过增加摩尔分数增加（α ₁ 的水溶助长剂（o -TDH / p -TDH）。负的β值表明非常有利的吸引力相互作用/协同作用，因为用于所需目的的两亲物总量减少，导致支出减少以及对生态的关注。获得的活度系数（f ₁和f ₂）始终低于1，这意味着在PMH和o -TDH / p -TDH之间发现了非理想性。像电导率方法一样，UV-可见技术和FT-IR技术也证明了PMH和o -TDH / p -TDH之间的相互作用。