Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disease (PNALD). Adverse effects of PN on other organ systems, such as brain and cardiovascular system, have been poorly studied. There have been several case reports, studies, and a recent animal study highlighting cardiotoxic effects of PN; however, much remains unclear about the underlying mechanisms causing cardiac damage. In this review, we propose a series of potential mechanisms behind PN-associated heart injury, and we provide an overview of therapeutic strategies and recent scientific advances.

肠外营养（PN）是一种挽救生命的营养疗法，适用于患者无法接受肠内营养的情况。然而，尽管 PN 具有多种益处，但它也存在多种副作用，最明显的是肠外营养相关肝病 (PNALD)。 PN 对其他器官系统（例如大脑和心血管系统）的不良影响的研究很少。有一些病例报告、研究和最近的一项动物研究强调了 PN 的心脏毒性作用；然而，导致心脏损伤的潜在机制仍不清楚。在这篇综述中，我们提出了 PN 相关心脏损伤背后的一系列潜在机制，并概述了治疗策略和最新的科学进展。