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Parenteral Nutrition and Cardiotoxicity

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Abstract

Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disease (PNALD). Adverse effects of PN on other organ systems, such as brain and cardiovascular system, have been poorly studied. There have been several case reports, studies, and a recent animal study highlighting cardiotoxic effects of PN; however, much remains unclear about the underlying mechanisms causing cardiac damage. In this review, we propose a series of potential mechanisms behind PN-associated heart injury, and we provide an overview of therapeutic strategies and recent scientific advances.

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Funding

The work was indirectly supported by the National Institutes of Health [Grants Numbers K08DK098623, R03EB015955-01] and the DeNardo Foundation. No direct funding was received related to this manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA

    Johan van Nispen, Marcus Voigt, Eric Song, Austin Armstrong, Margarita Fedorova, Vidul Murali, Joseph Krebs, Ashish Samaddar, Chandrashekhara Manithody & Ajay Jain

  2. Department of Surgery, Saint Louis University School of Medicine, Saint Louis, MO, 63103, USA

    Johan van Nispen & Marcus Voigt

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  1. Johan van Nispen
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van Nispen, J., Voigt, M., Song, E. et al. Parenteral Nutrition and Cardiotoxicity. Cardiovasc Toxicol 21, 265–271 (2021). https://doi.org/10.1007/s12012-021-09638-1

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