Clinical evidence shows that chronic pain and depression often accompany each other, but the underlying pathogenesis of comorbid chronic pain and depression remains mostly undetermined. Biotechnology is gradually revealing the phenotype and function of microglia, with great progress regarding microglia’s role in neurodegeneration, depression, chronic pain, and other conditions. This article summarizes the role of microglia in chronic pain, depression, and comorbidities, which is conducive to finding new targets to treat chronic pain and depression.

中文翻译：

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小胶质细胞在慢性疼痛和抑郁中的作用：无辜的旁观者还是罪魁祸首？

临床证据表明，慢性疼痛和抑郁症经常并存，但并存的慢性疼痛和抑郁症的潜在发病机制仍未确定。生物技术正在逐渐揭示小胶质细胞的表型和功能，关于小胶质细胞在神经退行性疾病，抑郁症，慢性疼痛和其他疾病中的作用方面取得了巨大进展。本文总结了小胶质细胞在慢性疼痛，抑郁和合并症中的作用，这有助于寻找治疗慢性疼痛和抑郁的新靶标。